Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist
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چکیده
منابع مشابه
Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist
Stable cyclic adenosine 5'-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca(2+) release mechanism and structure-activity relationships of this emerging potent second messenger. However, analogues with an intact "northern" ribose have been inaccessible due to the difficulty of generating the sensitive N1-ribosyl link. We report the first total synthesis of th...
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Cyclic adenosine 5'-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5'-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation. Replacing the base N9-ribose with a butyl chain generates inhibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 catalytic domain (shCD38), illustrating the nonessential nature o...
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Green, S. & Bodansky, 0. (1965) J. Biol. Chem. 240,25742579 Haines, M. E., Johnston, I. R., Mathias, A. P. & Ridge, D. (1969) Biochem. J . 115, 881-887 Kashnig, D. M. 19 Kasper, C. B. (1969) J. Biol. Clzem. 244, 3786-3792 Mamaril, F. P., Dobrjansky, A. & Green, S. (1970) Cancer Res. 30, 352-356 Mizuno, N. S., Stoops, C. E. & Sinha, A. A. (1971) Nature (London) New Biol. 229,22-24 Siebert, G. & ...
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Chromatin-bound poly(adenosine 5'-diphosphate IADPI-ribose) synthetase activity was highest in ungerminated wheat ( Triticum aestivum L., cv. Mukakomugi) embryos, and it decreased after germination within 14 hours. In contrast, transcriptional activity was lowest in ungerminated wheat embryos, and it increased during germination for 24 hours or more. Histones, Hi, H2A/H2B, basic nonhistone chro...
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Chromatin-bound poly(adenosine 5'-diphosphate [ADP]-ribose) synthetase activity was highest in ungerminated wheat (Triticum aestivum L., cv. Mukakomugi) embryos, and it decreased after germination within 14 hours. In contrast, transcriptional activity was lowest in ungerminated wheat embryos, and it increased during germination for 24 hours or more. Histones, H1, H2A/H2B, basic nonhistone chrom...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2012
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo202319f